Study Design: Dogs received D-penicillamine (12.5 mg/kg PO) fasted and with food in a randomized, crossover design to test the effect if food on the bioavailability.

Results: Coadministration of D-penicillamine with food significantly decreases plasma drug concentration. There were significant reductions in relative bioavailability and Cmax in fed dogs.

Conclusions: Decreased bioavailability can result in decreased copper chelation efficacy. Therefore administration of D-penicillamine with food cannot be categorically recommended.